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rEVO Biologics

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Atryn	Antithrombin (recombinant)	2009-02-06		Antithrombin iii deficiency

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Antithrombin alfa

congenital heart defects

,

,

postoperative hemorrhage

,

healthy volunteers/patients

,

,

,

liver cirrhosis

,

wounds and injuries

,

,

,

venous thromboembolism

,

thromboembolism

,

,

,

reperfusion injury

,

coronary artery bypass

,

cerebral infarction

,

,

ischemic stroke

,

respiratory distress syndrome

,

severe acute respiratory syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

hepatic veno-occlusive disease

,

,

small cell lung carcinoma

,

,

communicable diseases

,

blood coagulation disorders

,

hemostatic disorders

,

cardiopulmonary bypass

,

disseminated intravascular coagulation

,

,

extracorporeal membrane oxygenation

,

type 1 diabetes mellitus

,

,

non-hodgkin lymphoma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

antithrombin iii deficiency

,

,

,

venous thrombosis

,

,

myocardial infarction

,

,

cardiac surgical procedures

,

,

acute coronary syndrome

,

aortic valve stenosis

,

aortic valve insufficiency

,

mitral valve insufficiency

,

pathologic constriction

,

mitral valve stenosis

,

,

coagulation protein disorders

,

congenital disorders of glycosylation

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

sickle cell anemia

,

,

hemolytic anemia

,

,

thrombocytopenia

,

environmental biomarkers

,

,

,

,

factor xiii deficiency

,

migraine disorders

,

acute-phase reaction

,

antiphospholipid syndrome

,

,

,

hepatic insufficiency

,

nutritional requirements

,

cytokine release syndrome

,

,

upper extremity deep vein thrombosis

,

,

transfusion reaction

,

liver transplantation

,

,

heart septal defects

,

,

acute kidney injury

,

portal hypertension

,

,

budd-chiari syndrome

,

chronic renal insufficiency

,

kidney diseases

,

renal insufficiency

,

post-acute covid-19 syndrome

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

large b-cell lymphoma diffuse

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

,

,

,

hodgkin disease

,

mantle-cell lymphoma

,

b-cell lymphoma

,

triple negative breast neoplasms

,

renal cell carcinoma

,

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

parkinson disease

,

parkinsonian disorders

,

movement disorders

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

chronic renal insufficiency

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

graft vs host disease

,

type 1 diabetes mellitus

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

brain neoplasms

,

,

oligodendroglioma

,

pancreatic neoplasms

,

,

neuroendocrine tumors

,

islet cell carcinoma

,

,

,

somatostatinoma

,

,

,

breast neoplasms

,

myelodysplastic syndromes

,

thrombocytopenia

,

,

,

,

retinal vein occlusion

,

vision disorders

,

,

macular degeneration

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

juvenile arthritis

,

,

kidney diseases

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

organ transplantation

,

wet macular degeneration

,

neoplasm metastasis

,

graft rejection

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

non-alcoholic fatty liver disease

,

,

postoperative pain

,

,

choroidal neovascularization

,

pathologic neovascularization

,

chronic kidney failure

,

renal insufficiency

,

liver transplantation

,

kidney transplantation

,

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

liver cirrhosis

,

,

atrial fibrillation

Antithrombin iii

streptococcal infections

,

rectal neoplasms

,

,

atrial fibrillation

,

mantle-cell lymphoma

,

multiple myeloma

,

plasma cell neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

colonic neoplasms

,

streptococcus agalactiae

,

breast neoplasms

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

non-small-cell lung carcinoma

,

,

prostatic neoplasms

,

psoriatic arthritis

,

meningococcal infections

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

sickle cell anemia

,

,

renal cell carcinoma

,

,

,

vision disorders

,

,

,

meningococcal meningitis

,

,

thrombocytopenia

,

,

neuroendocrine tumors

,

,

myeloid leukemia

,

ovarian neoplasms

,

human influenza

,

myelodysplastic syndromes

,

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

hepatocellular carcinoma

,

carcinoid tumor

,

malignant carcinoid syndrome

,

serotonin syndrome

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

homozygous familial hypercholesterolemia

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

gastrointestinal stromal tumors

,

philadelphia chromosome

,

ovarian epithelial carcinoma

,

axial spondyloarthritis

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

graft vs host disease

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

rheumatoid arthritis

,

,

,

,

,

,

haemophilus influenzae

,

non-hodgkin lymphoma

,

b-cell lymphoma

,

,

hodgkin disease

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

follicular lymphoma

,

pancreatic neoplasms

,

,

myeloid leukemia chronic-phase

,

neuroendocrine carcinoma

,

,

,

essential hypertension

,

systolic murmurs

,

multiple sclerosis

,

neoplasm metastasis

,

chronic progressive multiple sclerosis

,

,

small cell lung carcinoma

healthy volunteers/patients

,

renal insufficiency

,

pharmacokinetics

,

biological availability

,

,

,

,

chronic kidney failure

,

kidney diseases

,

therapeutic equivalency

,

cardiovascular diseases

,

bariatric surgery

,

thromboembolism

,

venous thromboembolism

,

,

acute coronary syndrome

,

,

,

myocardial infarction

,

myocardial ischemia

,

,

,

transcatheter aortic valve replacement

,

,

percutaneous coronary intervention

,

unstable angina

,

knee osteoarthritis

,

hip osteoarthritis

,

,

,

,

coronavirus infections

,

,

respiratory insufficiency

,

communicable diseases

,

rheumatic diseases

,

collagen diseases

,

coronary disease

,

,

intracranial arteriosclerosis

,

arteriosclerosis

,

atrial fibrillation

,

,

,

venous thrombosis

,

pulmonary embolism

,

coronary artery disease

,

peripheral arterial disease

,

,

peripheral vascular diseases

,

,

disease progression

,

,

,

replacement arthroplasty knee

,

replacement arthroplasty hip

,

congenital heart defects

,

,

fontan procedure

Sodium chloride

,

,

,

,

,

,

depressive disorder

,

,

streptococcal infections

,

streptococcus agalactiae

,

,

acute kidney injury

,

wounds and injuries

,

,

,

aplastic anemia

,

,

hematologic neoplasms

,

,

cutaneous malignant melanoma

,

major depressive disorder

,

suicidal ideation

,

stomach neoplasms

,

bacterial infections

,

gram-positive bacterial infections

,

diabetic nephropathies

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

,

parkinson disease

,

healthy volunteers/patients

,

peritoneal neoplasms

,

intestinal obstruction

,

triple negative breast neoplasms

,

complex regional pain syndromes

,

reflex sympathetic dystrophy

,

somatoform disorders

,

,

,

congenital hyperinsulinism

,

nesidioblastosis

,

hyperinsulinism

,

,

eosinophilic esophagitis

,

,

sickle cell anemia

,

treatment-resistant depressive disorder

,

meningococcal infections

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

non-small-cell lung carcinoma

,

,

homozygous familial hypercholesterolemia

,

,

meningococcal meningitis

,

cardiovascular diseases

,

,

kidney diseases

,

renal cell carcinoma

,

,

cystic fibrosis

,

prostatic neoplasms

,

,

,

pancreatic neoplasms

,

chronic renal insufficiency

,

kidney transplantation

,

graft rejection

,

,

,

,

,

japanese encephalitis

,

respiratory tract infections

,

,

,

metabolic bone diseases

,

,

,

pulmonary eosinophilia

,

hepatocellular carcinoma

,

liver neoplasms

,

gastrointestinal stromal tumors

,

atherosclerosis

,

,

,

diabetes complications

,

vitreous hemorrhage

,

,

essential hypertension

,

metabolic syndrome

,

,

,

systolic murmurs

,

isolated systolic hypertension

,

neoplasm metastasis

,

,

human influenza

,

diabetes mellitus

,

multiple myeloma

,

plasma cell neoplasms

,

breast neoplasms

,

hypersensitivity

,

left ventricular hypertrophy

,

,

,

,

communicable diseases

,

,

diabetic retinopathy

,

,

insulin resistance

,

prehypertension

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

type 2 diabetes mellitus

,

,

,

retinal diseases

,

hip osteoarthritis

,

,

food hypersensitivity

,

abdominal obesity

,

retinal neovascularization

,

pathologic neovascularization

,

migraine disorders

,

migraine without aura

,

angina pectoris

,

microvascular angina

,

,

migraine with aura

,

health risk behaviors

,

vascular stiffness

healthy volunteers/patients

,

,

myeloid leukemia acute

,

myocardial infarction

,

,

ischemic stroke

,

,

,

inferior wall myocardial infarction

,

head and neck neoplasms

,

pulmonary embolism

,

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